Traditionally cancer is thought to originate from random genetic mutations that differ on a case by case basis. This conventional view has shaped current cancer treatment protocols and has led to costly, resource intensive, personalized cancer therapies. But what if these mutations are symptoms instead of the underlying root cause of cancer?
What if cancer is not a genetic disease?
At Tieös, we view these genetic mutations as a downstream phenomenon with inciting upstream metabolic aberrations and we are challenging current conventions with this idea. We believe cancer is a metabolic disease. This is why nearly all cancers are diagnosed with a metabolic test -- a PET scan, as most cancers share common metabolic features.
Cancer cells DO NOT use oxygen to make energy
The majority of cancer cells are unique from normal cells in that they do not use oxygen to create energy or ATP. This distinction, known as the Warburg effect, is one of many metabolic properties unique to cancer cells. Because of this metabolic defect, cancer cells must use other pathways to create energy in order to survive. They use glucose, glutamine, lactate and other amino acids at a disproportional rate compared to normal cells to compensate for this energy production crisis.
Cancer cells use different metabolic pathways for energy production
Cancer cells use different metabolic pathways for energy production -- and this can be targeted. These cancer specific targets are present in the vast majority of cancers, regardless of tissue origin. Tieös plans to exploit these unique behaviours, as it represents an untapped opportunity for cancer therapeutics.